miRNA targetstargets


MiRNA action is exerted by binding to their cognate targets (mainly at the 3'-UTR of the mRNAs from coding transcripts). These applications are designed for the analysis of predicted and validated miRNA targets.


Single applications

These are applications try to predict target binding sites for a specific miRNA or gene. The differences among applications are based on the algorithm used and also on different filtering factors such as the consideration of the secondary structure of the target mRNA.

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Multiple predictors

These applications are platforms that simultaneously scan several individual target predictors and present the results in a comparative way. They allow the use to determine if a particular miRNA target is predicted by one or more applications.

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Validated targets

These are manually curated databases that scan the published references for experimental evidences related with the regulatory effect of a particular miRNA over its cognate targets. Some of them allow to search for several criteria, including the experimental methods used for target validation.

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Integrative analysis

These applications fall over diverse classes, however they are mainly designed to infer the effect of several miRNAs over the transcriptomic or proteomic outputs. Typically they compare the expression levels of miRNAs and relate them with the mRNA levels of their predicted or validated targets in a particular experiment.

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Pathway analysis

The regulatory effect of miRNAs within biological processes is normally exerted by groups of these non-coding RNAs that act in a coordinate manner. In order to systematize the overall effect of the miRNA regulatory control, the clustering and grouping of the target genes has been recently explored. This section includes several server platforms to identify the cellular pathways potentially affected by a group of miRNAs.

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